Latest Research

Type VI CRISPR enzymes have been developed as programmable RNA-guided Cas proteins for eukaryotic RNA editing. Notably, Cas13 has been...

Adeno-associated virus (AAV) is a member of the genus Dependoparvovirus, which infects a wide range of vertebrate species. Here, we...

Precise targeting of large transgenes to T cells using homology-directed repair has been transformative for adoptive cell therapies and T...

Recombinant adeno-associated viral (AAV) vectors are a promising gene delivery platform, but ongoing clinical trials continue to...

The single-stranded DNA genome of adeno-associated viruses (AAV) undergoes second-strand synthesis and transcription in the host cell...

Adeno-associated viruses (AAV) rely on helper viruses to transition from latency to lytic infection. Some AAV serotypes are secreted in a...

Adeno-associated viruses utilize different glycans and the AAV receptor (AAVR) for cellular attachment and entry. Directed evolution has...

Preexisting humoral immunity to recombinant adeno-associated virus (AAV) vectors restricts the treatable patient population and efficacy...

Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach Approaches to engineer...

Mapping structural features of certain AAVs that enable transport across the brain vasculature Effective gene delivery to the CNS by...

A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes...

Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses Central...

Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription Adeno-associated viruses (AAV) are...

Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo Circular RNAs (circRNAs) are...